Transmasc Hormone Science 101
I'm curious to learn more about the specifics of different T preparations and methods, esp in terms of varying results. As far as I can tell, the assumption is that they're identical - they produce some masculinisation which is presumed to be what all transmasculine people ultimately want. But they don't - we're individuals - and so I'm interested to learn what, if anything, we can do to customise our outcomes more
All of these studies are of cis men, unless otherwise stated; some are cis men with particular conditions, or who are elderly, or part of particular groups. This may or may not be applicable to us. At the level I'm capable of, I can't say whether these impact transmasc people significantly or at all - but they are interesting, let's say. Experiment with as you wish.
Initial search: transgender testosterone on Pubmed, going back 5 years.
Discussion of what we know
Unfortunately, in regards to best practices surrounding fertility treatment and/or fertility preservation in transgender men, there seem to be more questions than answers from the available literature....As such, the current status quo is to recommend fertility preservation before initiation of T therapy and, for patients presenting subsequent to T therapy, cessation of T before ovarian stimulation....The long-term goal should be to equip medical providers with the information necessary to provide high-quality, data-driven counseling regarding fertility options for transgender men.
irk. Is this study for real? I have no idea what, if anything, this means for us. Congrats on having a bigger brain, I guess; you were right, The Patriarchy!
Testosterone produces structural changes in the brain as detected by quantitative magnetic resonance imaging. Mainly, it induces an increase in cortical volume and thickness and subcortical structural volume probably due to the anabolic effects.
I've heard through the grapevine that people with a uterus still feel monthly dysphoric peaks, following the ghost of their menstrual cycle. This study stood out as apparently validating this sense - our ability to complete logic tasks is cycle-dependent. I like that the study notes its intention is NOT to normalise like, cissexist frameworks around sex or gender, but to call for a deeper understanding of our hormonal situation.
Performance of TM- varied across the menstrual cycle, and matched that of menstrual phase-matched CW. Additionally, cycling individuals in Follicular performed as strongly as TM+ and CM, all of whom performed above individuals in Luteal...Rather than conforming to static categories that suggest sex- or gender-typical organization of cognitive circuits, our findings support dynamic shifts in visuospatial ability of TM, and illustrate the need to consider activating effects of hormones beyond GAHT
Looked at acne, male-pattern baldness, and body hair. Acne peaks at 6 months and is no issue longterm; ~30% of trans men after 10 years will have some kind of hairloss, but no one in the first year; and all but one were body-hairy longterm. They did not find results was related to a person's T or DHT levels.
Erythrocytosis is not a Greek fury, but the thing that leads to blood clots, deep vein thrombosis etc. This article was the subject of Letters to the Editor about whether hrt for trans men should therefore be prevented entirely, whether high BMI and smoking trans men should be prevented from having hormones, with the study authors defending the challenge that they ought to have assessed their patients using female reference ranges not male ones. Trans medicine, bro: I hate it here.
Erythrocytosis occurs in trans men using testosterone. The largest increase in hematocrit was seen in the first year, but also after the first years a substantial number of people present with hematocrit > 0.50 L/L. A reasonable first step in the care for trans men with erythrocytosis while on testosterone is to advise them to quit smoking, to switch to a transdermal administration route, and if BMI is high, to lose weight.
What they don't say here is they also found a raised risk in the long-acting undecanoate.
TM persons may experience modest increases in ALT and AST concentrations following testosterone initiation; however, clinical significance of the observed association remains unclear and requires further investigation...The influence of long-term GAHT on ALT and AST levels appears modest and not likely to reflect clinically meaningful changes in liver function.